nonhomologous end-joining

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'nonhomologous end-joining' can also refer to...

nonhomologous end-joining

Non-homologous end joining: advances and frontiers

Non-homologous end-joining factors of Saccharomyces cerevisiae

End-processing during non-homologous end-joining: a role for exonuclease 1

Distinct DNA repair pathways involving RecA and nonhomologous end joining in Mycobacterium smegmatis

PARP3 affects the relative contribution of homologous recombination and nonhomologous end-joining pathways

Lif1 SUMOylation and its role in non-homologous end-joining

Ribonucleotides and manganese ions improve non-homologous end joining by human Polµ

The role of DNA polymerase activity in human non-homologous end joining

Requirement for the SRS2 DNA helicase gene in non-homologous end joining in yeast

DNA repair of clustered lesions in mammalian cells: involvement of non-homologous end-joining

Smarcal1 promotes double-strand-break repair by nonhomologous end-joining

Tagging SNPs in non-homologous end-joining pathway genes and risk of glioma

Efficient processing of abasic sites by bacterial nonhomologous end-joining Ku proteins

End-bridging is required for pol μ to efficiently promote repair of noncomplementary ends by nonhomologous end joining

In vivo blunt-end cloning through CRISPR/Cas9-facilitated non-homologous end-joining

Nonhomologous end joining and homologous recombination DNA repair pathways in integration mutagenesis in the xylose-fermenting yeast Pichia stipitis

CtIP and MRN promote non-homologous end-joining of etoposide-induced DNA double-strand breaks in G1

Development of an assay to measure mutagenic non-homologous end-joining repair activity in mammalian cells


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The primary mammalian repair mechanism for reconnecting double-stranded breaks in DNA. A number of different proteins are involved, including DNA-dependent protein kinase catalytic subunit (DNA-PKcs), the Ku autoantigen, XRCC4, cernunnos, and DNA ligase IV. Synapsis results in the autophosphorylation of DNA-PKcs, making the DNA ends available for ligation. An equivalent mechanism is found in prokaryotes (see DNA ligases (DNA ligase D).

Subjects: Medicine and Health.

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