nonhomologous end-joining

Related Overviews


'nonhomologous end-joining' can also refer to...

nonhomologous end-joining

Non-homologous end joining: advances and frontiers

Non-homologous end-joining factors of Saccharomyces cerevisiae

End-processing during non-homologous end-joining: a role for exonuclease 1

Distinct DNA repair pathways involving RecA and nonhomologous end joining in Mycobacterium smegmatis

Tagging SNPs in non-homologous end-joining pathway genes and risk of glioma

Efficient processing of abasic sites by bacterial nonhomologous end-joining Ku proteins

Lif1 SUMOylation and its role in non-homologous end-joining

Ribonucleotides and manganese ions improve non-homologous end joining by human Polµ

The role of DNA polymerase activity in human non-homologous end joining

Requirement for the SRS2 DNA helicase gene in non-homologous end joining in yeast

DNA repair of clustered lesions in mammalian cells: involvement of non-homologous end-joining

PARP3 affects the relative contribution of homologous recombination and nonhomologous end-joining pathways

Smarcal1 promotes double-strand-break repair by nonhomologous end-joining

Dicer regulates non-homologous end joining and is associated with chemosensitivity in colon cancer patients

End-bridging is required for pol μ to efficiently promote repair of noncomplementary ends by nonhomologous end joining

In vivo blunt-end cloning through CRISPR/Cas9-facilitated non-homologous end-joining

RECQ helicase RECQL4 participates in non-homologous end joining and interacts with the Ku complex

Enhanced non-homologous end joining contributes toward synthetic lethality of pathological RAD51C mutants with poly (ADP-ribose) polymerase


More Like This

Show all results sharing this subject:

  • Medicine and Health


Show Summary Details

Quick Reference


The primary mammalian repair mechanism for reconnecting double-stranded breaks in DNA. A number of different proteins are involved, including DNA-dependent protein kinase catalytic subunit (DNA-PKcs), the Ku autoantigen, XRCC4, cernunnos, and DNA ligase IV. Synapsis results in the autophosphorylation of DNA-PKcs, making the DNA ends available for ligation. An equivalent mechanism is found in prokaryotes (see DNA ligases (DNA ligase D).

Subjects: Medicine and Health.

Reference entries

Users without a subscription are not able to see the full content. Please, subscribe or login to access all content.