The primary mammalian repair mechanism for reconnecting double-stranded breaks in DNA. A number of different proteins are involved, including DNA-dependent protein kinase catalytic subunit (DNA-PKcs), the Ku autoantigen, XRCC4, cernunnos, and DNA ligase IV. Synapsis results in the autophosphorylation of DNA-PKcs, making the DNA ends available for ligation. An equivalent mechanism is found in prokaryotes (see DNA ligases (DNA ligase D).
Subjects: Medicine and Health.