nonsense-mediated mRNA decay

'nonsense-mediated mRNA decay' can also refer to...

nonsense-mediated mRNA decay

Nonsense-Mediated mRNA Decay in Health and Disease

Alternative splicing and nonsense-mediated mRNA decay regulate mammalian ribosomal gene expression

A GFP-based reporter system to monitor nonsense-mediated mRNA decay

The ubiquitin-proteasome system and nonsense-mediated mRNA decay in hypertrophic cardiomyopathy

Differential nonsense mediated decay of mutated mRNAs in mismatch repair deficient colorectal cancers

Nonsense-mediated mRNA decay: from mechanistic insights to impacts on human health

The uORF-containing thrombopoietin mRNA escapes nonsense-mediated decay (NMD)

Long 3′-UTRs target wild-type mRNAs for nonsense-mediated mRNA decay in Saccharomyces cerevisiae

The nonsense-mediated mRNA decay pathway triggers degradation of most BRCA1 mRNAs bearing premature termination codons

Resistance of mRNAs with AUG-proximal nonsense mutations to nonsense-mediated decay reflects variables of mRNA structure and translational activity

Arabidopsis UPF1 RNA Helicase for Nonsense-mediated mRNA Decay is Involved in Seed Size Control and is Essential for Growth

Tissue-specific RNA surveillance? Nonsense-mediated mRNA decay causes collagen X haploinsufficiency in Schmid metaphyseal chondrodysplasia cartilage

SMG5–PNRC2 is functionally dominant compared with SMG5–SMG7 in mammalian nonsense-mediated mRNA decay

Characterization of SMG-9, an essential component of the nonsense-mediated mRNA decay SMG1C complex

Plant nonsense-mediated mRNA decay is controlled by different autoregulatory circuits and can be induced by an EJC-like complex

Saccharomyces cerevisiae Ebs1p is a putative ortholog of human Smg7 and promotes nonsense-mediated mRNA decay

Suppression of nonsense-mediated mRNA decay permits unbiased gene trapping in mouse embryonic stem cells

Contribution of copy number variants involving nonsense-mediated mRNA decay pathway genes to neuro-developmental disorders


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A mechanism for regulating gene expression in which mRNA is degraded because one exon contains a premature termination codon (PTC), in mammals, a termination codon more than ~50 nucleotides upstream of the final intron. It has been estimated that ~30% of alternatively spliced variants result in mRNA with such codons; if the exon containing the PTC is skipped, then the message is preserved.

http://www.ncbi.nlm.nih.gov/pubmed/14759258 Abstract of an article in Genome Biology (2004).

Subjects: Medicine and Health.

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