nonsense-mediated mRNA decay

'nonsense-mediated mRNA decay' can also refer to...

nonsense-mediated mRNA decay

Nonsense-Mediated mRNA Decay in Health and Disease

Nonsense-mediated mRNA decay: from mechanistic insights to impacts on human health

The ubiquitin-proteasome system and nonsense-mediated mRNA decay in hypertrophic cardiomyopathy

Differential nonsense mediated decay of mutated mRNAs in mismatch repair deficient colorectal cancers

The uORF-containing thrombopoietin mRNA escapes nonsense-mediated decay (NMD)

Alternative splicing and nonsense-mediated mRNA decay regulate mammalian ribosomal gene expression

A GFP-based reporter system to monitor nonsense-mediated mRNA decay

The nonsense-mediated mRNA decay pathway triggers degradation of most BRCA1 mRNAs bearing premature termination codons

Long 3′-UTRs target wild-type mRNAs for nonsense-mediated mRNA decay in Saccharomyces cerevisiae

Resistance of mRNAs with AUG-proximal nonsense mutations to nonsense-mediated decay reflects variables of mRNA structure and translational activity

Arabidopsis UPF1 RNA Helicase for Nonsense-mediated mRNA Decay is Involved in Seed Size Control and is Essential for Growth

Tissue-specific RNA surveillance? Nonsense-mediated mRNA decay causes collagen X haploinsufficiency in Schmid metaphyseal chondrodysplasia cartilage

Cloning, Sequence Analysis and Identification of a Nonsense Mutation-mediated mRNA Decay of Porcine GSTM2 Gene

Widespread predicted nonsense-mediated mRNA decay of alternatively-spliced transcripts of human normal and disease genes

SNP2NMD: A database of human single nucleotide polymorphisms causing nonsense-mediated mRNA decay

Contribution of copy number variants involving nonsense-mediated mRNA decay pathway genes to neuro-developmental disorders

Rent1, a trans-effector of nonsense-mediated mRNA decay, is essential for mammalian embryonic viability

hMRE11: genomic structure and a null mutation identified in a transcript protected from nonsense-mediated mRNA decay


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A mechanism for regulating gene expression in which mRNA is degraded because one exon contains a premature termination codon (PTC), in mammals, a termination codon more than ~50 nucleotides upstream of the final intron. It has been estimated that ~30% of alternatively spliced variants result in mRNA with such codons; if the exon containing the PTC is skipped, then the message is preserved.

http://www.ncbi.nlm.nih.gov/pubmed/14759258 Abstract of an article in Genome Biology (2004).

Subjects: Medicine and Health.

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