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An oncogene (nephroblastoma overexpressed) originally identified in an avian nephroblastoma (a model of Wilms’ tumour) and sequences homologous to nov were subsequently found to be expressed in normal haematopoietic cells and in a human nephroblastoma. The product (CCN3) is an immediate early gene product and a member of the CCN family of growth factors; aberrant expression is associated with vascular injury and reduced expression with malignant adrenocortical tumours.

Subjects: Medicine and Health.

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