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NS1


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Mutation analysis of a recombinant NS replicon shows that influenza virus NS1 protein blocks the splicing and nucleo-cytoplasmic transport of its own viral mRNA

Antiviral activity of baicalin against influenza virus H1N1-pdm09 is due to modulation of NS1-mediated cellular innate immune responses

Effect on Virulence and Pathogenicity of H5N1 Influenza A Virus through Truncations of NS1 eIF4GI Binding Domain

High mutation rate in the NS1 gene of parvovirus B19 DNA amplified from skeletal muscle of a case of mixed connective tissue disease

Slow and Fast Transitions in the Rising Phase of Outbursts from NS–LMXB Transients, Aquila X-1 and 4U 1608−52

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NS5A inhibitor resistance-associated polymorphisms in Brazilian treatment-naive patients infected with genotype 1 hepatitis C virus

Worldwide distribution of the NS3 gene 80K polymorphism among circulating hepatitis C genotype 1 viruses: implication for simeprevir usage

 

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1. A nonstructural protein, a nonessential virulence factor of influenza virus, that is found as a dimer in nuclei of infected cells. It inhibits immune responses, interferes with host mRNA processing, and inhibits production of inflammatory cytokines. The cellular NS1 binding protein (NS1BP, 619 aa) is found in nuclei as a dimer that colocalizes with spliceosomes. In infected cells NS1BP becomes more diffusely distributed.

2. See Noonan's syndrome.

Subjects: Medicine and Health.


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