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NS1


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1. A nonstructural protein, a nonessential virulence factor of influenza virus, that is found as a dimer in nuclei of infected cells. It inhibits immune responses, interferes with host mRNA processing, and inhibits production of inflammatory cytokines. The cellular NS1 binding protein (NS1BP, 619 aa) is found in nuclei as a dimer that colocalizes with spliceosomes. In infected cells NS1BP becomes more diffusely distributed.

2. See Noonan's syndrome.

Subjects: Medicine and Health.


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