An octagonally symmetrical organelle that allows controlled passage of molecules from nucleus to cytoplasm and vice versa. A typical mammalian nucleus contains between 3,000 and 4,000 NPCs. Each complex is made up of a central core that is formed from eight spokelike structures which encircle a central plug and are sandwiched between two rings. Cytoplasmic fibrils attach to the subunits that make up the outer cytoplasmic ring. A basket-like structure protrudes from the inner nuclear ring. It is composed of struts that connect subunits of this ring to a smaller terminal ring. See nucleoporins (Nups).
Subjects: Genetics and Genomics.