nuclear reprogramming

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Modifications of DNA (e.g., by demethylation) and/or chromatin proteins (e.g., by dissociation from DNA) that allow a differentiated nucleus from larval or adult somatic cells to replace an egg nucleus and restore totipotency (q.v.) to the transplanted nucleus. See Chronology, 2004, Simonssen and Gurdon; nuclear transfer.

Subjects: Genetics and Genomics.

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