An abundant, predominantly nucleolar phosphoprotein (NPM, B23, numatrin, NO38, 294 aa) involved in ribosome assembly and transport, trafficking from cytoplasm to nucleus, regulation of DNA polymerase α activity, centrosome duplication, regulation of ARF/p53 tumour suppressors and cellular responses to stress. Mutations in exon 12 of the nucleophosmin (NPM1) gene occur in about ~60% of cases of adult acute myeloid leukaemia (AML) with normal karyotype. Nucleophosmins 2 and 3 have similar properties. All three are related to Xenopus nucleoplasmin.
Subjects: Medicine and Health.