One of a family of receptor tyrosine kinases (neurotrophic tyrosine kinase receptor) for which the ligands are neurotrophins. NTRK1 (790 aa) binds nerve growth factor with high affinity. Mutations are associated with hereditary sensory neuropathy type IV (congenital insensitivity to pain and anhidrosis). Somatic rearrangements of NTRK1, producing chimeric oncogenes with constitutive tyrosine kinase activity (trk oncogene), occur in some papillary thyroid tumours.
Subjects: Medicine and Health.