1. A family of leucine zipper transcription factor genes (oct genes), the products of which act as RNA polymerase II promoters and bind to octamer sequences. Oct4 maintains the pluripotency of embryonic stem cells and in the expanding blastocyst is confined to the inner cell mass; as development proceeds it gradually disappears as the three germ layers become progressively differentiated.
2. OctN1 (solute carrier family 22, member 4, SLC22A4, 551 aa) is a proton/organic cation transporter involved in active secretion of cationic compounds, including xenobiotics, across the renal epithelial brush-border membrane. Mutations in OctN2 (SLC22A5), the sodium ion-dependent carnitine transporter, are responsible for systemic carnitine deficiency.
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