The proposal advanced by S. Ohno that the unique regulatory features of the X chromosomes dictate the evolutionary conservation of the primordial X-linkage group among mammals. Any translocation between the X chromosome and an autosome would disturb the dosage compensation mechanism, and therefore offspring bearing such a translocation would be eliminated. Therefore, if any gene is found to be sex-linked in a given species, such as Homo sapiens, it is likely to be X-linked in all other mammals. See Chronology, 1967, Ohno; dosage compensation.
Subjects: Genetics and Genomics.