Okazaki fragment

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Short fragments, a few hundred nucleotides long, discontinously synthesized in the 5′ to 3′ direction on the lagging strand of DNA that is being replicated by DNA polymerase. Synthesis on the leading strand occurs continuously at the replication fork (which is progressing in the 5′ to 3′ direction) as the duplex unzips. The Okazaki fragments are covalently linked by ligases to produce a continuous strand.

Subjects: Chemistry — Medicine and Health.

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