A physiological study in which one leg of each subject is treated differently to the other leg: for example, a group of subjects may perform one-leg endurance training on a cycle ergometer for several weeks. During such a study, physiological parameters of aerobic fitness (e.g. succinic dehydrogenase levels) can be compared in the trained and untrained leg. After the training period when one leg is well-trained, the subjects can perform a two-leg endurance exercise in which both legs perform identically. The effects of this exercise on the trained and untrained leg can be compared by means of arterial and venous catheterization and muscle biopsy analysis.
Subjects: Sports and Exercise Medicine.