'Orthomyxoviridae' can also refer to...


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The class V viruses, mostly influenza viruses. Their genome is a negative strand of RNA present as several separate segments, each a template for a single mRNA synthesized by a virus-specific RNA polymerase. The nucleocapsid is helical and they are budded from cells and enveloped in host plasma membrane in which virus-coded spike proteins are enriched. The spike proteins have haemagglutinin and neuraminidase activity (the basis for classification, e.g. H5N1), both being important in the invasion of cells by the virus.

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