One of the tumour necrosis factor (TNF) superfamily, a cytokine (ODF, receptor activator of NFκB ligand, RANKL, 317 aa) that regulates differentiation of the immune system as well as bone metabolism. Mice deficient in RANKL have defects in early thymocyte development. RANKL-RANK signalling is essential for osteoclast development and bone destruction. Inhibition of RANKL either by the decoy receptor osteoprotegerin or by anti-RANKL antibody, may be therapeutically beneficial in osteoporosis and rheumatoid arthritis.
Subjects: Medicine and Health.