osteogenesis imperfecta

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(fragilitas ossium) a congenital disorder of connective tissue formation that affects bone, teeth, and soft tissues. It has an incidence of 1 in 20,000 and there are four types, of varying severity, the worst being lethal at birth. In all types the bones are brittle and fracture easily; the sclerae may be blue and teeth are often deformed.

Subjects: Medicine and Health — Chemistry.

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