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One of the claudin protein family (claudin-16, 305 aa) expressed at tight junctions of renal epithelial cells of the thick ascending limb of the loop of Henle, with an important role in the reabsorption of divalent cations. Mutations in the paracellin-1 gene cause familial hypomagnesaemia with hypercalciuria and nephrocalcinosis (FHHNC).

Subjects: Medicine and Health.

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