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(PTH-RP) a protein that is secreted by certain malignant tumours and is the main cause of malignant hypercalcaemia. PTH-RP, which has effects similar to parathyroid hormone, stimulates generalized bone resorption and excessive calcium reabsorption in the kidney tubules. It is most commonly produced by lung tumours, squamous-cell carcinomas of other organs, melanomas, and tumours of the breast, liver, pancreas, bladder, and prostate.
Subjects: Chemistry.
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