Overview

PARP-1


'PARP-1' can also refer to...

PARP‐1

Update on PARP1 inhibitors in ovarian cancer

ADP-ribosyltransferases Parp1 and Parp7 safeguard pluripotency of ES cells

PARP-2 and PARP-3 are selectively activated by 5′ phosphorylated DNA breaks through an allosteric regulatory mechanism shared with PARP-1

PARP1 suppresses homologous recombination events in mice in vivo

Visualization of a DNA-PK/PARP1 complex

PARP1 is required for adhesion molecule expression in atherogenesis

PARP-1 regulates epithelial–mesenchymal transition (EMT) in prostate tumorigenesis

PARP inhibition versus PARP-1 silencing: different outcomes in terms of single-strand break repair and radiation susceptibility

O6.1Classification of PARP inhibitors based on PARP trapping and catalytic inhibition, and rationale for combinations

BRCA1, PARP, and 53BP1: conditional synthetic lethality and synthetic viability

PARP1–TDP1 coupling for the repair of topoisomerase I–induced DNA damage

PARP-1 cooperates with Ptc1 to suppress medulloblastoma and basal cell carcinoma

PARP1 ADP-ribosylates lysine residues of the core histone tails

ARF induction in response to DNA strand breaks is regulated by PARP1

Poly(ADP‐ribose) polymerase (PARP‐1) has a controlling role in homologous recombination

Nuclear PARP-1 protein overexpression is associated with poor overall survival in early breast cancer

PARP Inhibitors for BRCA1/2 mutation-associated and BRCA-like malignancies

PARP-1 suppresses adiponectin expression through poly(ADP-ribosyl)ation of PPARγ in cardiac fibroblasts

 

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abbr. for poly(ADP‐ribose) polymerase 1; in mammals, a highly conserved protein (113 kDa) that is strongly activated by DNA strand breaks, and participates in modulating DNA base excision repair, apoptosis ...

Subjects: Chemistry.


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