Overview

PARP-2


'PARP-2' can also refer to...

PARP‐2

PARP-2 and PARP-3 are selectively activated by 5′ phosphorylated DNA breaks through an allosteric regulatory mechanism shared with PARP-1

ISY-5-2HBOC management in PARP inhibitor development: Japanese perspective

PARP Inhibitors for BRCA1/2 mutation-associated and BRCA-like malignancies

The PARP inhibitor Olaparib disrupts base excision repair of 5-aza-2′-deoxycytidine lesions

Single molecule detection of PARP1 and PARP2 interaction with DNA strand breaks and their poly(ADP-ribosyl)ation using high-resolution AFM imaging

Poly (ADP-ribose) polymerase (PARP) inhibitors for the treatment of advanced germline BRCA2 mutant prostate cancer

Poly(ADP-ribose) polymerase 2 localizes to mammalian active centromeres and interacts with PARP-1, Cenpa, Cenpb and Bub3, but not Cenpc

PARP-1 Hyperactivation and Reciprocal Elevations in Intracellular Ca2+ During ROS-Induced Nonapoptotic Cell Death

PARP-2 domain requirements for DNA damage-dependent activation and localization to sites of DNA damage

Window study of the PARP inhibitor rucaparib in patients with primary triple negative or BRCA1/2 related breast cancer (RIO)

Outcomes of clinical testing for tumor BRAC1 and BRCA2 gene analysis for 354 patients: first experience with tumor companion diagnostic for PARP inhibitors

964PModeling and impact of organ function on the population pharmacokinetics (PK) of niraparib, a selective poly (ADP-Ribose) polymerase (PARP)-1 and -2 inhibitor

HG-05DIFFERENTIAL EXPRESSION OF PARP1/2 AS A BIOMARKER OF DIPG MALIGNANT PROGRESSION: RELATIONSHIP TO TGF-β/BMP SIGNALING AND EZH2 GLOBAL METHYLATION

Differential contribution of poly(ADP-ribose)polymerase-1 and -2 (PARP-1 and -2) to the poly(ADP-ribosyl)ation reaction in rat primary spermatocytes

2,3,7,8-Tetrachlorodibenzo-p-dioxin poly(ADP-ribose) polymerase (TiPARP, ARTD14) is a mono-ADP-ribosyltransferase and repressor of aryl hydrocarbon receptor transactivation

Clinical activity of the poly(ADP-ribose) polymerase (PARP) inhibitor rucaparib in patients (pts) with high-grade ovarian carcinoma (HGOC) and a BRCA mutation (BRCAmut): Analysis of pooled data from Study 10 (parts 1, 2a, and 3) and ARIEL2 (parts 1 and 2)

 

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abbr. for poly(ADP‐ribose) polymerase 2; in mammals, a 62 kDa protein that catalyses poly(ADP‐ribose) formation, being activated by DNA strand breaks. Its activity supplements that of PARP‐1 in mouse gene knockouts for this protein.

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Subjects: Chemistry.


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