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A subfamily of the peptidyl prolyl cis/trans isomerases (PPIases), highly conserved in all metazoans. Parvulin 14 (PIN4) is preferentially located in the mitochondrial matrix. The human parvulin PIN1 (EC is a nuclear protein implicated in the regulation of mitosis through interaction with CDC25 and polo-like kinase-1.

Subjects: Medicine and Health.

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