PAS genes

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Genes that are essential for the biogenesis and proliferation of peroxisomes in yeast. The human gene PXR1 (peroxisome biogenesis factor 5, PEX5) is the homologue of Pichia pastoris PAS8 and encodes the receptor for the peroxisomal targeting signal type 1. Mutations in PEX5 are associated with neonatal adrenoleukodystrophy and Zellweger's syndrome.

Subjects: Medicine and Health.

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