A subset of Pax genes (q.v.) that encode evolutionarily conserved transcription factors essential for eye development in insect and mammalian species. In Drosophila, the Pax-6 genes (q.v.) are eyeless (ey) and twin of eyeless (toy); in humans and rodents, the Pax-6 genes are Aniridia (q.v.) and Small eye (q.v.), respectively.
Subjects: Genetics and Genomics.