p34 (CDC2)

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A protein of relative molecular mass 34,000, hence the p34 designation. It functions in cell division control, hence the CDC acronym. This protein belongs to the Ser/Thr family of protein kinases (q.v.). CDC2 contains 297 amino acids, and phosphorylation at Thr-161 activates it, whereas phosphorylation at Thr-14 or Tyr-15 inactivates it. When combined with cyclin B, it forms the mitosis-promoting factor (MPF) (q.v.). For this reason CDC2 is sometimes called CDK2 (cyclin-dependant kinase-2). CDK2 is responsible for the separation of centrioles, the first step in centrosome duplication. In humans the gene for CDC2 contains 15,688 bases and has been mapped to 10q21.1. Homologous genes have been found in the mouse, Drosophila, Xenopus, Caenorhabditis, and Schizosaccharomyces.

Subjects: Genetics and Genomics.

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