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A transcriptional repressor (polycomb group RING finger protein 2, 344 aa) involved in polycomb repressive complex 1 (PRC1). It has tumour suppressor activity and may play a role in control of cell proliferation and/or neural cell development. Regulates proliferation of early T progenitor cells by maintaining expression of HES1 and plays a role in anteroposterior specification of the axial skeleton and negative regulation of the self-renewal activity of haematopoietic stem cells.

Subjects: Medicine and Health.

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