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A transcription factor (pancreas–duodenum homeobox-1, insulin promoter factor 1, somatostatin transcription factor-1, 283 aa) that regulates the development of both the exocrine and endocrine pancreas and transcription of the insulin gene. Some mutations can lead to pancreatic agenesis, others to increased susceptibility to type 2 diabetes.

Subjects: Chemistry — Medicine and Health.

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