Overview

PEA-15


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An acidic serine-phosphorylated protein (phosphoprotein enriched in astrocytes, 15 kDa, 130 aa) containing a death effector domain that colocalizes with microtubules. It is highly expressed in the central nervous system, where it apparently protects against cytokine-induced apoptosis. It is phosphorylated in astrocytes by CaMKII (or a related kinase) and by protein kinase C in response to endothelin; the phosphorylation state may determine whether PEA-15 influences proliferation or apoptosis.

Subjects: Medicine and Health.


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