A set of disorders in which there are episodes of partial paralysis of muscles. Hyperkalaemic periodic paralysis (HYPP) is caused by mutation in the voltage-gated sodium channel gene SCN4A (see paramyotonia congenita). Hypokalaemic periodic paralysis (HOKPP) can be caused by mutations in the gene encoding a subunit of the L-type calcium channel (CACNL1A3) or in the SCN4A gene. Thyrotoxic periodic paralysis can be caused by a mutation in the voltage-regulated potassium channel, KCNE3. See also Andersen's syndrome.
Subjects: Medicine and Health.