A protein that is exposed on the outer or the inner surface of the plasma membrane and is connected to the membrane through ionic or covalent interactions with a membrane component. Peripheral proteins include many proteins from the membrane-supporting cytoskeleton (e.g., spectrin (q.v.) or the extracellular matrix (e.g., fibronectin (q.v.). Compare with integral protein. See lipid bilayer model.
Subjects: Chemistry — Genetics and Genomics.