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PH-30


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One subunit (β-fertilin, ADAM2) of a heterodimeric sperm surface protein involved in sperm–egg fusion. The α subunit (ADAM1) has some similarities to viral fusion proteins, and the β subunit has an ADAM domain (a disintegrin and metalloprotease domain) similar to that in soluble integrin ligands (disintegrins). The first 382 aa (16 aa of signal sequence and the metalloprotease domain) are cleaved from the 735-aa precursor.

Subjects: Medicine and Health.


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