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phosducin


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A phosphoprotein (246 aa) found in retina, pineal gland, and many other tissues, that inhibits Gs-GTPase activity by binding the Gβγ subunit of heterotrimeric G proteins, making them unavailable for signalling. Phosphorylation by protein kinase A inhibits its activity. The phosducin gene is a potential candidate gene for retinitis pigmentosa and Usher's syndrome (type II). Three phosducin-like proteins with extensive amino acid sequence homology to phosducin have been identified.

Subjects: Medicine and Health — Chemistry.


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