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Intermediates in glycolysis (2-phosphoglycerate and 3-phosphoglycerate) and, in the case of 3-phosphoglycerate, the precursor for synthesis of phosphatidic acid and diacylglycerol. Phosphoglycerate kinase (PGK, EC, 417 aa) is an X-linked enzyme that catalyses the phosphorylation of 3-phospho-d-glycerate to 3-phosphohydroxypyruvate in glycolysis. The phosphoglycerate mutase (EC, 254 aa) family is widely distributed with tissue-specific isoforms; deficiency of the muscle form leads to myopathy similar to that caused by deficiency in phosphofructokinase.

Subjects: Medicine and Health — Chemistry.

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