An integral membrane protein (a homopentamer with subunits of 52 aa) that is the endogenous regulator of the calcium ATPase of sarcoplasmic reticulum (SERCA). Phosphorylation by protein kinase A blocks the inhibition which can be reversed by protein phosphatase 1 dephosphorylation. Mutations affect control of cardiac muscle and cause dilated cardiomyopathy. See sarcolipin.
Subjects: Medicine and Health — Chemistry.