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Any enzyme that catalyses the hydrolysis of one of the two ester linkages in a phosphodiester. PDE-I (EC catalyses the removal of 5-nucleotides from the 3′-end of an oligonucleotide. PDE-II (EC catalyses removal of 3-nucleotides from the 5′-end of a nucleic acid. The term is often used as a shorthand for cAMP-phosphodiesterase. See cyclic nucleotide phosphodiesterases.

Subjects: Chemistry — Medicine and Health.

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