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The NADPH oxidase system in phagocytes, that produces reactive oxygen species through the metabolic burst and is important for bacterial killing. The membrane-associated portion is a heterodimer of p22phox and p91phox, the A and B subunits of cytochrome b245. Two other components, p47phox and p67phox, are cytoplasmic and only become membrane-associated following activation. Both p47 and p67 contain SH3 domains. Deletion or mutation in any of the components can cause chronic granulomatous disease although the commonest form involves mutation in p91.

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