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Microarray expression analysis and identification of serum biomarkers for Niemann–Pick disease, type C1

Microglia activation in Niemann–Pick disease, type C1 is amendable to therapeutic intervention

Cholesterol homeostatic responses provide biomarkers for monitoring treatment for the neurodegenerative disease Niemann–Pick C1 (NPC1)

NPC1 defect results in abnormal platelet formation and function: studies in Niemann–Pick disease type C1 patients and zebrafish

Defective nitric oxide-dependent, deaminative cleavage of glypican-1 heparan sulfate in Niemann–Pick C1 fibroblasts

The Extending Spectrum of NPC1-Related Human Disorders: From Niemann–Pick C1 Disease to Obesity

Protein interacting with C kinase (PICK1) is a suppressor of spinocerebellar ataxia 3-associated neurodegeneration in Drosophila

Disruption and therapeutic rescue of autophagy in a human neuronal model of Niemann Pick type C1

Ryanodine receptor antagonists adapt NPC1 proteostasis to ameliorate lipid storage in Niemann–Pick type C disease fibroblasts

Efficacy of N-acetylcysteine in phenotypic suppression of mouse models of Niemann–Pick disease, type C1

Autophagy in Niemann–Pick C disease is dependent upon Beclin-1 and responsive to lipid trafficking defects

Defective endocytic trafficking of NPC1 and NPC2 underlying infantile Niemann–Pick type C disease

Rescue of neurodegeneration in Niemann–Pick C mice by a prion-promoter-driven Npc1 cDNA transgene

OxLDL up-regulates Niemann–Pick type C1 expression through ERK1/2/COX-2/PPARα-signaling pathway in macrophages

A novel mouse model of Niemann–Pick type C disease carrying a D1005G-Npc1 mutation comparable to commonly observed human mutations


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A neuronal protein (protein interacting with C kinase-1) that is phosphorylated by protein kinase C and interacts with the GTP-bound forms of ADP-ribosylation factor-1. It binds AMPA receptors and acid-sensing ion channels and may regulate Golgi-to-endoplasmic reticulum vesicle transport.

http://www.endocytosis.org/BARdomains/BARs.html Further details in the BAR Superfamily website.

Subjects: Medicine and Health.

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