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PI-3-kinases


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'PI-3-kinases' can also refer to...

PI-3-kinases

Molecular targeting: PI3 kinase pathway

PI 3—kinase and cancer metabolism

100 Role of PI3kinase and p70S6kinase activation in delayed preconditioning

Functional studies of the PI(3)‐kinase signalling pathway employing synthetic and expressed siRNA

Ras, PI3-kinase and mTOR signaling in cardiac hypertrophy

PI 3-kinase regulates the mitochondrial transition pore in controlled reperfusion and postconditioning

Involvement of the PI 3-kinase signaling pathway in progression of colon adenocarcinoma

Myricetin inhibits UVB-induced angiogenesis by regulating PI-3 kinase in vivo

PI 3-kinase, protein kinase C, and protein kinase A are involved in the trigger phase of β1-adrenergic preconditioning

73PEXPRESSION OF PHOSPHORYLATED PROTEINS FROM PI3-KINASE AND MAP-KINASE SIGNALING PATHWAYS IN INFILTRATING BREAST CANCER: RELATION WITH HISTOPATHOLOGIC AND MOLECULAR SUBTYPES

Infarct size limitation by adrenomedullin: protein kinase A but not PI3-kinase is linked to mitochondrial KCa channels

Reduced PTEN expression in breast cancer cells confers susceptibility to inhibitors of the PI3 kinase/Akt pathway

NT-17TREATMENT OF DIFFUSE INTRINSIC PONTINE GLIOMA (DIPG) WITH AN ONCOLYTIC MEASLES VIRUS IN COMBINATION WITH INHIBITORS OF THE PI3-KINASE PATHWAY

SC-31RATIONAL DESIGN OF A PI3-KINASE/mTOR INHIBITOR CYTOTOXIC TO BRAIN CANCER STEM CELLS UNDER HYPOXIA

Insulin attenuates apoptosis induced by high glucose via the PI3-kinase/Akt pathway in rat peritoneal mesothelial cells

Identification of novel synergistic targets for rational drug combinations with PI3 kinase inhibitors using siRNA synthetic lethality screening against GBM

Physiological concentrations of insulin induce endothelin-mediated vasoconstriction during inhibition of NOS or PI3-kinase in skeletal muscle arterioles

Ischemic postconditioning protects remodeled myocardium via the PI3K–PKB/Akt reperfusion injury salvage kinase pathway

 

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A family of kinases (phosphatidylinositol-3-kinases, PI kinases) that phosphorylate phosphatidylinositol phosphate on the 3 position. They are involved in signalling cascades downstream of many growth factor receptors, particularly receptor tyrosine kinases (RTKs). The classical form (class I) has a p110 enzymatic subunit which is regulated by p85 (p85α, p85β, p55γ, and splicing variants). p110 is recruited to the membrane and activated via the interaction of SH2 domains on the regulatory subunit which bind phosphotyrosine motifs on the stimulated RTK. An increasing family is being identified, including the PI3Kγ isoform which is activated by receptor-stimulated G proteins and recruited to the membrane by p101. Others are regulated by calcium. Most, but not all, are inhibited by wortmannin. See Akt.

Subjects: Medicine and Health.


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