A family of giant multidomain proteins that link cytoskeletal elements together and connect them to junctional complexes. Plakins were first identified in epithelial cells connecting intermediate filaments to desmosomes and hemidesmosomes, and splicing isoforms have subsequently been shown to be important for the integrity of muscle cells and crosslinking of microtubules (MTs) and actin filaments in neurons. One member is bullous pemphigoid antigen 1 (Bpag1)/dystonin, which has neuronal and muscle isoforms that have actin-binding and microtubule-binding domains at either end separated by a plakin domain and several spectrin repeats. See epiplakin.
Subjects: Medicine and Health.