Transmembrane receptors for the semaphorins with homology to the MET-hepatocyte growth factor receptor tyrosine kinase family. At least nine members of the family are known although the specific roles of each are poorly defined. Nomenclature is idiosyncratic (plexin 4 is SEX, plexin 5 is SEP, plexin 2 is OCT, and plexin 1 is NOV) but will probably be rationalized. Plexin domain-containing protein 2 (tumour endothelial marker 7-related protein, 529 aa) may be involved in tumour angiogenesis.
Subjects: Chemistry — Medicine and Health.