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poliovirus


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The cause of poliomyelitis (infantile paralysis). It is a positive-stranded RNA virus with a 6.1 kb genome. Enormous polysomes (q.v.) containing 60 or more ribosomes occur in infected cells. The entire genome is translated from a single initiation site to form a single polyprotein molecule. This is subsequently cleaved into both structural and nonstructural proteins. The structural proteins assemble to form the icosahedral capsule of the virus. The virus is remarkably stable, and it has been successfully grown from archaeological specimens centuries old. See icosahedron.

Subjects: Chemistry — Genetics and Genomics.


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