Proteins (PABPs) that are complexed to the 3′ poly-A tail of mRNA and are required for poly-A shortening and initiation of translation through an interaction with translation initiation factor EIF4G1. PABP1 is involved in nuclear events associated with the formation and transport of mRNP to the cytoplasm. There are PABP-interacting proteins (PAIP1, 480 aa) that are also involved in initiating translation. PAIP2 (127 aa) competes with PAIP1 for binding to PABP.
Subjects: Medicine and Health.