poly(ADP-ribose) polymerase

'poly(ADP-ribose) polymerase' can also refer to...

poly(ADP-ribose) polymerase

poly(ADP‐ribose) polymerase

The clinical development of inhibitors of poly(ADP-ribose) polymerase

Poly(ADP-ribose) polymerase activation in the reperfused myocardium

Genetic Alteration of Poly(ADP-ribose) Polymerase-1 in Human Germ Cell Tumors

Anticancer Chemosensitization and Radiosensitization by the Novel Poly(ADP-ribose) Polymerase-1 Inhibitor AG14361

Poly(ADP-ribose) polymerase inhibition attenuates biventricular reperfusion injury after orthotopic heart transplantation

Inhibiting poly(ADP-ribose) polymerase: a potential therapy against oligodendrocyte death

Increased susceptibility of poly(ADP-ribose) polymerase-1 knockout mice to nitrosamine carcinogenicity

Poly(ADP-ribose) polymerase activity is not affected in ataxia telangiectasia cells and knockout mice

Deletion in poly(ADP-ribose)polymerase pseudogene and lung cancer risk.

Functional overexpression of human poly(ADP-ribose) polymerase in transfected rat tumor cells.

Poly(ADP-ribose) polymerase-2 depletion reduces doxorubicin-induced damage through SIRT1 induction

Poly(ADP-ribose) polymerase at active centromeres and neocentromeres at metaphase

Poly(ADP-ribose) polymerases covalently modify strand break termini in DNA fragments in vitro

Bookmarking promoters in mitotic chromatin: poly(ADP-ribose)polymerase-1 as an epigenetic mark

Inhibition of poly(ADP-ribose) polymerase activity is insufficient to induce tetraploidy

Poly(ADP‐ribose) polymerase (PARP‐1) has a controlling role in homologous recombination

Crystal structure of the catalytic fragment of murine poly(ADP‐ribose) polymerase‐2


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A chromatin-associated enzyme (PARP, EC, 1013 aa) that catalyses the covalent transfer of 60–80 ADP-ribose units to a variety of nuclear proteins. It is activated by DNA nicks and is important in DNA repair. Other members of the PARP family may regulate gene transcription by altering chromatin organization as a result of histone polyadenylation.

Subjects: Medicine and Health.

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