polyglutamine disease

'polyglutamine disease' can also refer to...

polyglutamine disease

polyglutamine disease

Polyglutamine diseases: emerging concepts in pathogenesis and therapy

Oligonucleotide-based strategies to combat polyglutamine diseases

The pathogenic agent in Drosophila models of ‘polyglutamine’ diseases

Microarrays and polyglutamine disorders: reports from the Hereditary Disease Array Group

Evidence for Proteasome Involvement in Polyglutamine Disease: Localization to Nuclear Inclusions in SCA3/MJD and Suppression of Polyglutamine Aggregation in vitro

Polyglutamine Diseases: Where does Toxicity Come from? What is Toxicity? Where are We Going?

Association of polyalanine and polyglutamine coiled coils mediates expansion disease-related protein aggregation and dysfunction

Comparative toxicity of polyglutamine, polyalanine and polyleucine tracts in Drosophila models of expanded repeat disease

A polyglutamine expansion disease protein sequesters PTIP to attenuate DNA repair and increase genomic instability

Reduction of polyglutamine toxicity by TDP-43, FUS and progranulin in Huntington's disease models

Rilmenidine attenuates toxicity of polyglutamine expansions in a mouse model of Huntington's disease

Antioxidants can inhibit basal autophagy and enhance neurodegeneration in models of polyglutamine disease

Accumulation of aberrant ubiquitin induces aggregate formation and cell death in polyglutamine diseases

Suppression of polyglutamine-induced toxicity in cell and animal models of Huntington's disease by ubiquilin

Mechanisms of chaperone suppression of polyglutamine disease: selectivity, synergy and modulation of protein solubility in Drosophila

Unbiased screen identifies aripiprazole as a modulator of abundance of the polyglutamine disease protein, ataxin-3

Glial expression of disease-associated poly-glutamine proteins impairs the blood–brain barrier in Drosophila


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Any disease of humans caused by the expansion of a CAG trinucleotide repeat in a gene. On expression, the region that contains the elongated stretch of glutamine repeats misfolds and ...

Subjects: Chemistry.

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