A highly conserved peripheral membrane protein (rapsyn, 412 aa) that anchors nicotinic acetylcholine receptors in the postsynaptic membrane. Mutations in rapsyn can be one cause of congenital myasthenic syndrome. Postsynaptic density proteins (PSD proteins) are a family of proteins involved in the clustering of receptors on the postsynaptic cell. The PSD-95 protein (synapse-associated protein 90, 723 aa) is a membrane-associated guanylate kinase (MAGUK) responsible for the clustering of NMDA receptors and potassium channels; a similar protein is responsible for the formation of synaptic complexes. See AKAP family; neurabin; neuroligins.
Subjects: Medicine and Health.