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Class I viruses with a double-stranded DNA genome that encodes more than 30 polypeptides. They are the largest viruses and have a complex multilayered coat composed of lipid and enzymes, including a DNA-dependent RNA polymerase. They multiply in the cytoplasm of the cell. Four genera cause human infections: orthopox, parapox, yatapox, and molluscipox. Important examples are vaccinia, variola (smallpox), and myxoma.

Subjects: Medicine and Health.

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