A family of nuclear hormone receptors (peroxisome proliferator-activated receptors, PPARα, γ1, γ2, and δ) that are implicated in metabolic disorders predisposing to atherosclerosis and inflammation. PPARα stimulates β-oxidative degradation of fatty acids and is activated by gemfibrozil and other fibrate drugs. PPARγ promotes lipid storage by regulating adipocyte differentiation. PPAR-binding protein (PPARBP, 1581 aa) is a transcriptional coactivator for PPAR and for other nuclear receptors. PPARγ coactivator-1 (PGC, 910 aa) is a transcriptional coactivator involved in various aspects of energy metabolism including regulation of the expression of uncoupling proteins. Various other coactivators have been identified. The PPARα-interacting cofactor complex (PRIC285, 2649 aa) is a nuclear transcriptional coactivator for PPARα and -γ, as well as various other nuclear receptors.
Subjects: Medicine and Health.