Overview

primase


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An enzyme that creates the short primer sequences needed for the discontinuous replication of DNA. It is an RNA polymerase that synthesizes a short segment of RNA, consisting of 10 to 12 nucleotides, attached to the lagging strand of the unwound DNA molecule. Each primer sequence provides the free 3′ –OH group required for the initiation of synthesis of an Okazaki fragment by DNA polymerase. These primers are subsequently removed before the Okazaki fragments are united into a continuous new DNA strand. See also primosome.

Subjects: Chemistry — Biological Sciences.


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