'progranulin' can also refer to...



Targeted manipulation of the sortilin–progranulin axis rescues progranulin haploinsufficiency

Plasma progranulin levels predict progranulin mutation status in frontotemporal dementia patients and asymptomatic family members

Frontotemporal lobar degeneration through loss of progranulin function

Progranulin plasma levels in the diagnosis of frontotemporal dementia

Novel splicing mutation in the progranulin gene causing familial corticobasal syndrome

Mutations in progranulin explain atypical phenotypes with variants in MAPT

Multiple therapeutic effects of progranulin on experimental acute ischaemic stroke

Progranulin protects against the tissue damage of acute ischaemic stroke

Cortical Atrophy and Language Network Reorganization Associated with a Novel Progranulin Mutation

Phenotype variability in progranulin mutation carriers: a clinical, neuropsychological, imaging and genetic study

Progranulin gene mutations associated with frontotemporal dementia and progressive non-fluent aphasia

The neuropathology of frontotemporal lobar degeneration caused by mutations in the progranulin gene

TDP-43 pathology in familial frontotemporal dementia and motor neuron disease without Progranulin mutations

Neuroimaging signatures of frontotemporal dementia genetics: C9ORF72, tau, progranulin and sporadics

Reduction of polyglutamine toxicity by TDP-43, FUS and progranulin in Huntington's disease models

Variations in the progranulin gene affect global gene expression in frontotemporal lobar degeneration

Mutations in progranulin are a major cause of ubiquitin-positive frontotemporal lobar degeneration


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A glycoprotein growth factor (epithelin precursor, proepithelin, acrogranin, 593 aa) that has seven similar cysteine-rich domains; these are cleaved from progranulin and some were originally isolated as granulins (granulins A–D). Progranulin is expressed in many epithelial cells, macrophages, and monocyte-derived dendritic cells and is involved in multiple physiological and pathological processes. The granulins are also active in various processes. Mutations in the progranulin gene have been shown to cause familial frontotemporal lobar degeneration with ubiquitin-positive inclusions (FTDL-U). Progranulin mediates proteolytic cleavage of TDP-43 to generate ~35-kDa and ~25-kDa species.

Subjects: Medicine and Health.

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