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prosaposin


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The glycoprotein (sphingolipid activator protein, sulphated glycoprotein-1, SGP-1, 524 aa) produced in testis, spleen, and brain from which saposins are produced by proteolysis. There are two alternative transcripts, one targeted to the lysosome in a mannose-6-phosphate-independent manner apparently involving sortilin, whereas the other is secreted. Inhibitors of sphingolipid biosynthesis, such as fumonisin B1 and tricyclodecan-9-yl xanthate potassium salt, interfere with the trafficking of prosaposin to lysosomes.

Subjects: Medicine and Health — Chemistry.


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