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protein kinase A


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(PKA)

A family of serine/threonine kinases (PKA, cAMP-dependent protein kinase, EC 2.7.11.1) regulated by the level of cyclic AMP in the cell. They have two catalytic subunits and two regulatory subunits that undergo a conformational change when they bind cAMP and activate the catalytic subunits. A diverse range of substrates gives pleiotropic effects.

Subjects: Chemistry.


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