A family of protein kinase C (PKC)-related serine/threonine kinases, probably regulated by rho-dependent phosphorylation. PKN1 (PRK-1, 942 aa) is ubiquitously expressed and is activated by phospholipids and arachidonic acid. PKN2 (PRK-2, PAK-2, 984 aa) is activated by cardiolipin and acidic phospholipids, and interacts with Nck and PLCγ. PKN3 is reportedly required for invasive prostate cell growth and is regulated by PI3K. See polo-like kinases.
Subjects: Medicine and Health.